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During a promotional event in Chicago, Jamie meets Maggie Murdock (played by Anne Hathaway), a beautiful and free-spirited woman who is a drug representative for a competing company. The two engage in a casual conversation, and Jamie is immediately drawn to Maggie's charming and outgoing personality.
The narrative follows Jamie Randall (Gyllenhaal), a charismatic and ambitious salesman who finds his niche as a pharmaceutical representative for Pfizer during the late 1990s boom of drugs like Zoloft and Viagra. His professional life is a whirlwind of "physician schmoozing" and cutthroat sales tactics. However, his superficial lifestyle is upended when he meets Maggie Murdock (Hathaway), a free-spirited artist living with early-onset Parkinson’s disease.
